Abstract Plumula Nelumbinis (PN) has been traditionally consumed as a health food with therapeutic applications, including inflammation and hematemesis. However, its effect on gastric health remains unexplored yet. In this study, we discovered that orally administered 300 mg/kg PN extract exhibited a gastro-protective effect in hydrochloric acid/ethanol-induced gastritis mouse models. Our findings revealed a significant gastro-protective effect accompanied by an elevation in gastric PGE₂ levels and a reduction in total NO concentration. Notably, mucus production and secretion were prominently up-regulated by PN extract treatment. We further demonstrated that PN extract and its purified phytochemicals, such as schaftoside and narcissoside stimulated TRPM5 and the Na⁺/Ca²⁺ exchanger-dependent Ca²⁺ entry. These findings collectively underscore PN extract as a beneficial dietary option for promoting gastric healing. Our study will encourage an expanded investigation into its mechanistic and clinical applications.