Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction
- Year
- 2022
- Author
- Hyungsup Kim a , Hyesu Kim a,b , Luan Thien Nguyena,c , Taewoong Ha a , Sujin Lim a,c , Kyungmin Kim a , Soon Ho Kim a , Kyungreem Han a , Seung Jae Hyeona , Hoon Ryua , Yong Soo Park d , Sang Hyun Kim d , In-Beom Kim d , Gyu-Sang Honga , Seung Eun Lee a
- Journal
- Progress in Neurobiology
- Vol.
- ( IF: 10.885 / JCR: 7.445 )
A B S T R A C T
Sensing smells of foods, prey, or predators determines animal survival. Olfactory sensory neurons in the olfactory
epithelium (OE) detect odorants, where cAMP and Ca2+play a significant role in transducing odorant inputs to
electrical activity. Here we show Anoctamin 9, a cation channel activated by cAMP/PKA pathway, is expressed in
the OE and amplifies olfactory signals. Ano9-deficient mice had reduced olfactory behavioral sensitivity, electro-
olfactogram signals, and neural activity in the olfactory bulb. In line with the difference in olfaction between
birds and other vertebrates, chick ANO9 failed to respond to odorants, whereas chick CNGA2, a major transduction
channel, showed greater responses to cAMP. Thus, we concluded that the signal amplification by ANO9
is important for mammalian olfactory transduction.